Loprazolam

Also known as: Loprazolam Mesylate, Loprazolam Methanesulphonate

Drug #1739

Loprazolam is an intermediate-acting benzodiazepine with actions and general properties similar to those of diazepam. Loprazolam is used as a hypnotic in the short-term management of insomnia.

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Primary Characteristics

Loprazolam is also known as Loprazolam Mesylate, Loprazolam Methanesulphonate.

It is of Synthetic origin and belongs to Benzodiazapine.

Molecular Weight: 579 · Solubility in Water: Slightly soluble · Solubility in Alcohol: Slightly soluble · Non-proprietary name: Loprazolam.

Pharmacokinetics

None recorded.

Indications

Loprazolam is primarily indicated in conditions like Insomnia, Nausea, vertigo, labyrinthine disorders.

Contraindications

Loprazolam is contraindicated in conditions like Myasthenia gravis, Respiratory depression, Sleep apnea syndrome, Acute pulmonary insufficiency.

Dosage

Loprazolam's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.75 mg	0.75 mg	Every 24h	PO	Dose can be increased to 2 mg if necessary.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Moderate6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

The signs and symptoms that are produced after acute overdosage of Loprazolam are Coma, CNS depression.

Loprazolam is known to cause more or less tolerable side effects which are usually transient. These include Amnesia , Ataxia, Confusion, Dependence , Drowsiness, Dysarthria , Dysuria, GI disturbance, Light-headedness, Muscle weakness, Salivation changes, Skin reactions, Tremor, Vertigo.

Warnings / Precautions

Loprazolam should be used with caution in patients with respiratory disease, muscle weakness, history of drug or alcohol abuse, marked personality disorder; avoid regular use during pregnancy (risk of neonatal withdrawl symptoms); use only if clear indication such as seizure control (high doses during late pregnancy or labour may cause neonatal hypothermia, hypotonia and respiratory depression); breast-feeding (present in milk, avoid if possible); reduce dose in elderly and debilitated, and in hepatic (avoid if severe) and renal impairment (start with small doses if severe); avoid prolong use (abrupt withdrawl thereafter); porphyria. It should not be used alone to treat depression (or anxiety associated with depression) or psychosis

Available Brands

None recorded.

Drug Classification

1.24.3 — Drugs used in anxiety and sleep disorders