Mepacrine (HCl)
Mepacrine (HCl) is an antiprotozoal agent. Mepacrine (HCl) is an acridine derivative, widely used during the second world war as an antimalarial agent, but now Mepacrine (HCl) is no longer used for this purpose, rather more safer and newer drugs are preferred. Mepacrine (HCl) is mainly used for the treatment of giardiasis. It has also been used locally for the treatment of certain cutaneous leishmaniasis.
Primary Characteristics
Molecular Weight: 508.91 · Solubility in Water: 2.8gm/100ml · Non-proprietary name: Mepacrine (HCl).
Pharmacokinetics
Distribution: Mepacrine (HCl) has a plasma protein binding is 80-90%.
Elimination: plasma half-life is 5-14 days, renal excretion is Urine.
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Indications
Mepacrine (HCl) is primarily indicated in conditions like Discoid lupus erythematosus, Giardiasis.
Contraindications
Mepacrine (HCl) is contraindicated in conditions like Psoriasis, Alcohol abuse, Hypersensitivity to the drug.
Dosage
Mepacrine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 100 mg | 100 mg | Every 8h | PO | Should be given for 5 to 7 days. |
| Paediatric Dosage (20kg) | ||||
| 2 mg/kg | 2 mg/kg | — | Maximum 300mg daily. | |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Mepacrine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include CNS stimulation, Dizziness, GI disturbance, Headache, Nausea and vomiting, Transient acute toxic psychosis, Yellow discolortaion of skin and urine.
Warnings / Precautions
Available Brands
None recorded.
Drug Classification
- 1.6.4.3 — Antimalarials