DrugInfoSys

Tenofovir Disoproxil

Drug #1730

A nucleoside reverse transcriptase inhibitor (antiviral drug), which is used in the treatment of HIV infection. There is no cure for HIV infection, so the objective of the treatment is just to reduce the viral load for extended period of time. To obtain best possible results, it is given in combination with other antiretroviral drugs. Varrying degrees of cross-resistance to tenofovir may occur by preexisting Zidovudine-associated mutations (permanent changes in genetic material). Gastrointestinal complaints are the most common side effects, but usually do not require discontinuation of therapy.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Adenosine analog.

It belongs to Antiviral Agents pharmacological group on the basis of mechanism of action.

Non-proprietary name: Tenofovir Disoproxil.

Molecular structure of Tenofovir Disoproxil

Pharmacokinetics

None recorded.

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Indications

Tenofovir Disoproxil is primarily indicated in conditions like HIV infection, HIV infection in combination with other antiretroviral drugs.

Contraindications

Tenofovir Disoproxil is contraindicated in conditions like Breast feeding.

Dosage

Tenofovir Disoproxil's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
300 mg300 mg—PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

6 interactions
Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Tenofovir Disoproxil is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Flatulence, Hypophosphatemia, Nausea and vomiting.

Warnings / Precautions

Tenofovir Disoproxil should be used with caution in patients with renal impairment, test renal function and serum phosphate before treatment, then every 4 weeks (weekly if given with nephrotoxic drug e.g cidofovir), interrupt treatment if renal function deteriorates or serum phosphate decreases; pregnancy (use only if potential benefit outweighs risk).

Interference in Pathology

Tenofovir Disoproxil may interfere in the diagnosis of Elevation in ALT or AST, Elevated liver enzymes.

Available Brands

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Single Ingredient

Tabs
300 mg

Storage Conditions

Tenofovir Disoproxil should be stored Tabs.

Drug Classification

  1. 1.6.5.2 — Antiretroviral drugs

Manufacturers