Botulinum B Toxin

Drug #1714

Botulinum B Toxin is an exotoxin produced by germinating spores and growing cells of Clostridium botulinum. It binds to presynaptic terminals of the central nervous system and inhibits the calcium-ion mediated release of acetylcholine at the motor nerve terminals, leading to flaccid paralysis of the affected muscles. Paralysis persists for about 2-3 months (until new nerve terminals form). The actions and uses are similar to those of Botulinum type A toxin, but due to antigenically distinct they have the potential for use in patients who develop resistance to botulinum toxin treatment due to the development of antibodies of type A toxin.

← Previous drug Next drug →

Primary Characteristics

It is of Natural origin and belongs to Purified neurotoxin complex.

Molecular Weight: 150804 · Non-proprietary name: Botulinum B Toxin · pH: 5.6.

Molecular structure of Botulinum B Toxin

Pharmacokinetics

None recorded.

Indications

Botulinum B Toxin is primarily indicated in conditions like spasmodic torticolis.

Contraindications

Botulinum B Toxin is contraindicated in conditions like Pregnancy, Breast feeding, Prophylaxis of angina; adjunct in CHF.

Dosage

Botulinum B Toxin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
7500 units	7500 units	—	IM	administer in 2 to 4 divided doses.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Botulinum B Toxin produces potentially life-threatening effects which include Muscle weakness. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Botulinum B Toxin are Burning sensation, Hypertonia, Bruising, Weakness .

Botulinum B Toxin is known to cause more or less tolerable side effects which are usually transient. These include Dry mouth, Dyspepsia , Dysphagia, Myasthenia, Neck pain, Taste disturbances, Voice changes, Worsening torticollis.

Warnings / Precautions

Inadvertant injection into a blood vessel; tolerance may occur. It should be given with extreme caution to pateints with neurological disorders

Available Brands

None recorded.

Storage Conditions

Botulinum B Toxin should be stored Inj.

Drug Classification

1.9.2 — Drugs used in essential tremor & related disorders