DrugInfoSys

Esomeprazole

Drug #1685

Esomeprazole is an ulcer-healing drug, that inhibits gastric acid by blocking the proton-pump (Hydrogen-Potassium atpase enzyme system) of the gastric perital cells. Esomeprazole is used for the short-term treatment of gastric and duodenal ulcers and in gastro-oesophageal reflux disease with severe symptoms. Esomeprazole is also used in combination with antibacterials for the eradication of Helicobacter pylori.

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Primary Characteristics

Esomeprazole is also known as Esomeprazole Magnesium trihydrate.

It is of Synthetic origin and belongs to Sulphinyl Benzimidazol.

Molecular Weight: 345.4 · Solubility in Water: InSoluble · Solubility in Alcohol: Soluble · Non-proprietary name: Esomeprazole.

Molecular structure of Esomeprazole

Pharmacokinetics

Absorption: Esomeprazole has an oral bioavailability is 69.5% (±19.5%).

Distribution: Esomeprazole has a plasma protein binding is 97%.

Elimination: it is metabolised via Liver, plasma half-life is 1.2hour, renal excretion is Urine.

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Indications

Esomeprazole is primarily indicated in conditions like Gastric ulcer, Gastro-esophageal reflux disease, NSAID-associated ulceration, Zollinger-ellison syndrome.

Esomeprazole is also indicated for secondary conditions like Pernicious anaemia and other macrocytic anaemias.

Contraindications

Esomeprazole is contraindicated in conditions like Hypersensitivity to the drug.

Dosage

Esomeprazole's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
0 – 0 mg—Every 24hIV-InjContinue until oral administration possible.
20 – 0 mg—Every 24hPOMaintenance
20 – 40 mg—Every 24hPOInitially for 4-8 weeks.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Esomeprazole in overdosage may give rise to further complications which include Liver damage .

The signs and symptoms that are produced after acute overdosage of Esomeprazole are Ataxia, Tremor, Change in respiratory frequnecy, Intermediate Chronic Convulsion.

Esomeprazole is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Arthralgia, athralgia, Blurred vision, Constipation , Diarrhea, Dizziness, Dry mouth, Fatigue, Flatulence, Headache, Malaise, Musculoskeletal pain , Myalgia, Nausea and vomiting, Pruritus , Rashes , subacute myopathy.

Warnings / Precautions

Esomeprazole should be given with caution in patients with renal impairment, liver disease, in pregnancy and in breast-feeding. Proton-pump inhibitors may mask symptoms of gastric cancer, particular care is required in those whose symptoms change and in those over 45 years of age; the presence of gastric malignancy should be excluded before treatment.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps
10 mg20 mg
Caps
40 mg
Inf
40 mg
Inj
20 mg40 mg
Inj-IV
40 mg
Tabs
10 mg20 mg40 mg5 mg

Multi-Ingredient Combinations

Caps
20 mg40 mg

Storage Conditions

Esomeprazole should be stored .

Drug Classification

  1. 1.17.1.2 — Anti-peptic ulcerants

Manufacturers

Manufacturers of Esomeprazole in Pakistan:

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