Rosuvastatin

Drug #1675

Rosuvastatin is a lipid regulating drug, belongs to statins. Rosuvastatin is a selective, competitive inhibitor of HMG-CoA reductase, an enzyme involved in the synthesis of cholesterol in the liver. Rosuvastatin is used in the treatment of primary hypercholesterolaemia, mixed dyslipidaemias or homozygous familial hypercholesterolaemia in patients who have not responded adequately to diet and other appropriate measures. Statins are more effective than other classes in lowering the LDL-cholesterol, they reduce coronary events, all cardiovascular events, and total mortality.

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Primary Characteristics

Rosuvastatin is also known as Rosuvastatin Calcium.

It is of Synthetic origin.

Molecular Weight: 1001.14 · Non-proprietary name: Rosuvastatin.

Pharmacokinetics

Distribution: Rosuvastatin has a volume of distribution is 134litres. plasma protein binding is 90%.

Elimination: it is metabolised via Hepatic, renal excretion is 5% in urine.

Indications

Rosuvastatin is primarily indicated in conditions like Hypercholesterolaemia, Hyperlipidaemia.

Rosuvastatin is also indicated for secondary conditions like Hypertriglyceridaemia.

Contraindications

Rosuvastatin is contraindicated in conditions like Liver diseases, Renal impairment, Pregnancy, Lactation, Hypersensitivity to any component of product.

Dosage

Rosuvastatin's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
12.5 mg/day	12.5 mg/day	—	PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Rosuvastatin produces potentially life-threatening effects which include Abdominal pain, Myalgia . Careful monitoring is needed with proper medical management.

Rosuvastatin is known to cause more or less tolerable side effects which are usually transient. These include Asthenia , Dizziness, Headache, Hypersensitivity , Nausea, Pancreatitis.

Warnings / Precautions

Rosuvastatin therapy should be discontinued if markedly elevated creatinine kinase levels occur or myopathy is diagnosed or suspected. Rosuvastatin therapy should also be temporarily withheld in any patient with an acute, serious condition suggestive of myopathy or predisposing to the development of renal failure secondary to rhabdomyolysis.Should be used with caution in patients who consume substantial quantities of alcohol and/or have a history of chronic liver disease

Interference in Pathology

Rosuvastatin may interfere in the diagnosis of Elevations of SGPT and SGOT , Elevation in ALT or AST.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

10 mg 20 mg 40 mg 5 mg

Multi-Ingredient Combinations

Tabs

10 mg 5 mg

Storage Conditions

Rosuvastatin should be stored Tabs.

Drug Classification

1.12.6 — Lipid-regulating drugs /Anti-atheromas

Manufacturers

Manufacturers of Rosuvastatin in Pakistan: