Torasemide

Also known as: Torsemide

Drug #1662

Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonylurea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension.

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Primary Characteristics

Torasemide is also known as Torsemide.

It is of Synthetic origin.

Molecular Weight: 348.43 · pK_a: 7.1 · Solubility in Water: 5.96e-02 mg/mL · Non-proprietary name: Torasemide.

Pharmacokinetics

Absorption: Torasemide has an oral bioavailability is 80%.

Distribution: Torasemide has a plasma protein binding is >99%.

Elimination: plasma half-life is 3.5 hours.

Indications

Torasemide is primarily indicated in conditions like Congestive heart failure, Edema, Hepatic disease, Hypertension, Renal diseases.

Contraindications

Torasemide is contraindicated in conditions like Rheumatic disease (pain and inflammation), Pain and inflammation in rheumatic disease.

Dosage

None recorded.

Drug Interactions

22 interactions

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

The signs and symptoms that are produced after acute overdosage of Torasemide are Hypotension, Hemoconcentration, Hypochloremic alkalosis, Dehydration, Hypokalemia , Hypovolemia, Hyponatremia.

Warnings / Precautions

Torasemide should be used with caution in patients with hepatic disease with cirrhosis and ascites, since sudden alterations of fluid and electrolyte balance may precipitate hepatic coma. In these patients, diuresis with Torasemide (or any other diuretic) is best initiated in the hospital. To prevent hypokalemia and metabolic alkalosis, an aldosterone antagonist or potassium-sparing drug should be used concomitantly with Torasemide.

Available Brands

None recorded.

Drug Classification

1.16.2 — Loop diuretics