Methotrimeprazine(HCl)

Also known as: Levomepromazine[HCl]

Drug #1640

Methotrimeprazine(HCl) is phenothiazine with actions and pharmacological properties similar to that of both clorpromazine and promethazine. Methotrimeprazine(HCl) is used intramuscularly (IM), in the treatment of various psychoses including schizopherenia, as an adjunct to analgesics in the management of severe terminal pain. Methotrimeprazine (HCl) is also used as a premedicant and is given prior to surgical procedures.

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Primary Characteristics

Methotrimeprazine(HCl) is also known as Levomepromazine[HCl].

It is of Synthetic origin and belongs to Phenothiazine.

Molecular Weight: 365 · pK_a: 9.15 · Solubility in Water: freely soluble · Solubility in Alcohol: freely soluble · Non-proprietary name: Methotrimeprazine(HCl).

Molecular structure of Methotrimeprazine(HCl)

Pharmacokinetics

Absorption: Methotrimeprazine(HCl) has an pre-systemic (first-pass) metabolism accounts for 25% (±25%).

Distribution: Methotrimeprazine(HCl) has a volume of distribution is 23-40 l/kg. plasma protein binding is Very high.

Elimination: it is metabolised via Liver, plasma half-life is 15-30 hr.

Indications

Methotrimeprazine(HCl) is primarily indicated in conditions like Anxiety, Moderate to severe pain, Psychosis, Schizophrenia.

Contraindications

Methotrimeprazine(HCl) is contraindicated in conditions like Bone marrow depression, Coma, Heart disease, Close-angle glaucoma.

Dosage

Methotrimeprazine(HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
18.75 mg	18.75 mg	—	IM
15.5 mg/day	15.5 mg/day	—	PO	For minor conditions: should be given in 3 divided doses.Increase the dosage until the optimum level has been reached.
62.5 mg/day	62.5 mg/day	—	PO	For severe conditions: should be given in 2-3 divided doses.Increase the dosage until the optimum level has been reached.
112.5 mg	112.5 mg	—	S/C	Frequency could be 3-4 times a day
Paediatric Dosage (20kg)
400 mg	400 mg	—	IV or S/C
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Methotrimeprazine(HCl) in overdosage may give rise to further complications which include Maculopathy , Tardive dyskinesia , Paralytic ileus , Seizures , Respiratory distress, Lens opacities .

Methotrimeprazine(HCl) produces potentially life-threatening effects which include Agranulocytosis, Malignant neuroplastic syndrome. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Methotrimeprazine(HCl) are Drowsiness, Tachycardia , Hypothermia, Severe extrapyramidal dyskinesias, ECG alterations, Ventricular arrhythmias, Loss of conciousness, Hypotension.

Methotrimeprazine(HCl) is known to cause more or less tolerable side effects which are usually transient. These include Asthenia , Contact dermatitis, Dry mouth, Erythematous rash, Hypotension , Parkinsonism, Photosensitivity, Sedation , Weight gain.

Warnings / Precautions

Methotrimeprazine should be used in low initial dose. Monitor pulse and blood pressure until dosage requirements and responses are stabilized in elderly and debilitated patients.

Interference in Pathology

Methotrimeprazine(HCl) may interfere in the diagnosis of Estimation Tests of serum and urinary Cortisol .

Available Brands

None recorded.

Storage Conditions

Methotrimeprazine(HCl) should be stored .

Drug Classification

1.24.1 — Drugs used in psychotic disorders