Co-Amoxiclav

Drug #1621

Co-Amoxiclav is a combined preparation of amoxicillin with beta-lactamase inhibitor clavulanic acid. Amoxicillin is a beta-lactam antibiotic, a derivative of ampicillin with a similar bacterial spectrum, but Co-Amoxiclav is inactivated by beta-lactamases (enzymes produced by some bacteria). Clavulanic acid itself has no significant antibacterial activity, but by inactivating beta-lactamases, it makes the combination active against beta-lactamase-producing bacteria that are resistance to amoxicillin.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Amoxycillin+Clavulanic Acid.

Non-proprietary name: Co-Amoxiclav.

Pharmacokinetics

None recorded.

Indications

Co-Amoxiclav is primarily indicated in conditions like Dental infections, Hyperlipidaemias, Lower respiratory tract infections, Overdosage with opioids, Soft tissue and skin infections, Surgical prophylaxis, Upper respiratory tract infections, Urinary tract infection.

Contraindications

Co-Amoxiclav is contraindicated in conditions like Penicillin hypersensitivity.

Dosage

Co-Amoxiclav's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
513.5 mg	513.5 mg	Every 8h	PO	Doses vary according to indication. Use 1g/dose in severe infections. To minimize potential gastrointestinal intolerance and to optimize absorption of drug, administer at the start of a meal
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Co-Amoxiclav in overdosage may give rise to further complications which include Convulsions , Hepatitis , Cholestatic jaundice , Epidermal necrolysis , Stevens johnson syndrome , Angioedema , Interstitial nephritis , Exfoliative dermatitis , Oedema , Erythema multiforme, Reversible hemolytic anemia, Reversible leucopenia, Erythematous rash, Urticarial rash, Reversible thrombocytopenia.

Co-Amoxiclav produces potentially life-threatening effects which include Anaphylaxis , Hypersensitivity vasculitis, Severe sickness like syndrome. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Co-Amoxiclav are Electrolyte disturbances, Fluid disturbance.

Co-Amoxiclav is known to cause more or less tolerable side effects which are usually transient. These include Candidiasis , Colitis, Diarrhea, Dizziness, Headache, Hyperactivity, Indigestion , Nausea and vomiting.

Warnings / Precautions

It should be used with caution in patients with hepatic dysfunction, patients on anticoagulant therapy and in combination with broad spectrum antibiotics. Its use should be avoided in pregnancy.

Available Brands

None recorded.

Drug Classification

1.6.2.1.1 — Penicillins