Sodium Clodronate

Also known as: Clodronic Acid, Clodronate Disodium, Clodronate Sodium, Disodium Clodronate

Drug #1612

Sodium Clodronate is a bisphosphonate. It inhibits bone resorption without affecting absorption. Sodium Clodronate is also used as an adjunct in the treatment of severe hypercalcemia. Common adverse effects include gastrointestinal disturbances.

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Primary Characteristics

Sodium Clodronate is also known as Clodronic Acid, Clodronate Disodium, Clodronate Sodium, Disodium Clodronate.

It is of Synthetic origin and belongs to Biphosphonate.

Molecular Weight: 360.9 · pK_a: 1.0 , 1.8, 6, 9.5 · Solubility in Water: soluble · Non-proprietary name: Sodium Clodronate.

Molecular structure of Sodium Clodronate

Pharmacokinetics

Absorption: Sodium Clodronate has an oral bioavailability is 2.5% (±1.5%).

Distribution: Sodium Clodronate has a volume of distribution is 16-33 litre. plasma protein binding is 2.1-7.1%.

Elimination: plasma half-life is 1.8-2.3 hr, renal excretion is 70%.

Indications

Sodium Clodronate is primarily indicated in conditions like Hypercalcaemia, Hypercalcaemia associated with malignancy, Hypercalcaemia of malignancy, Osteolytic bone metastases, Osteolytic lesions.

Contraindications

Sodium Clodronate is contraindicated in conditions like Renal insufficiency.

Dosage

Sodium Clodronate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
800 mg	800 mg	Every 12h	PO	The capsules should be taken with a little fluid, but not milk, at least 1 hour before or 1 hour after food. If necessary, the dose may be increased but should not exceed a maximum of 3200 mg sodium clodronate daily.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Sodium Clodronate produces potentially life-threatening effects which include Acute Renal Failure . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Sodium Clodronate are Acute renal failure.

Sodium Clodronate is known to cause more or less tolerable side effects which are usually transient. These include Flushing, Hypocalcemia, Nausea, Vomiting .

Warnings / Precautions

Adequate fluid intake must be maintained during sodium clodronate treatment. This is particularly important when administering sodium clodronate as intravenous infusion and in patients with hypercalcemia or renal failure. Intravenous administration of doses notably higher than those recommended may cause severe renal damage especially if the infusion rate is too high.

Available Brands

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Single Ingredient

Caps

400 mg

Inj

60 mg/ml

Storage Conditions

Sodium Clodronate should be stored Inj, caps.

Drug Classification

1.18.14 — Drugs affecting bone metabolism

Manufacturers

Manufacturers of Sodium Clodronate in Pakistan:

Bayer