Escitalopram
Escitalopram is an isomer of citalopram, an antidepressant that selectively inhibits reuptake of serotonin (5-HT) i.e belongs to SSRIs (selective serotonin release inhibitors). Escitalopram is effective in the treatment of depression, and panic disorders.
Primary Characteristics
Escitalopram is also known as Escitalopram Oxalate.
It is of Synthetic origin.
Molecular Weight: 414.4 · Non-proprietary name: Escitalopram.
Pharmacokinetics
Distribution: Escitalopram has a volume of distribution is 12 L/kg. plasma protein binding is 56%.
Elimination: it is metabolised via hepatic, plasma half-life is 27-59 hrs.
Advertisement
Indications
Escitalopram is primarily indicated in conditions like Depression, Depressive illness, Panic disorders, Social anxiety disorder.
Contraindications
Escitalopram is contraindicated in conditions like Serotonin syndrome.
Dosage
Escitalopram's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5 – 20 mg | — | Every 24h | PO | Generalized Anxiety Disorder: Initial treatment: 10 mg, then maintenance dose is 20 mg. If the dose is increased to 20 mg, this should occur after a minimum of one week. Maintenance Treatment Generalized anxiety disorder is recognized as a chronic condition. The efficacy of Lexapro in the treatment of GAD beyond 8 weeks has not been systematically studied. The physician who elects to use Escitalopram for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Escitalopram in overdosage may give rise to further complications which include Bleeding .
Escitalopram produces potentially life-threatening effects which include Hemorrhage , Serotonin syndrome, Neuromascular syndrome. Careful monitoring is needed with proper medical management.
Escitalopram is known to cause more or less tolerable side effects which are usually transient. These include Anorgasmia in women, Anxiety, Decrease in libido, Decreased appetite, Dizziness, Ejaculatory disturbances, Fatigue, GI upset, Insomnia, Nausea, Pyrexia , Sexual dysfunction, Sinusitis , Somnolence , Sweating , Tremor.
Warnings / Precautions
Interference in Pathology
Escitalopram may interfere in the diagnosis of Urinanalysis .
Available Brands
Drug Classification
- 1.24.2.1 — Drugs used in depression
Manufacturers
Manufacturers of Escitalopram in Pakistan: