Cilastatin (Na)
Cilastatin (Na) is an aihibitor of enzyme dehydropeptidase I, found in the brush border of the renal tubules. Cilastatin (Na) is administered concomitantly with the antibiotic Imipenem to prevent its renal metabolism to microbiologically inactive and potentially nephrotoxic products. Cilastatin has no bacterial activity itself, and does not affect the antibacterial activity of imipenem.
Primary Characteristics
It is of Synthetic origin and belongs to Amino Acid.
Molecular Weight: 380.4 · Solubility in Water: soluble in water · Solubility in Alcohol: soluble in alcohol · Non-proprietary name: Cilastatin (Na) · pH: 6.3.
Pharmacokinetics
None recorded.
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Indications
Cilastatin (Na) is primarily indicated in conditions like Small cell carcinoma.
Contraindications
Cilastatin (Na) is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
None recorded.
Drug Interactions
None recorded.
Side Effects
Cilastatin (Na) is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, Blood disorders, Confusion, Diarrhea, Fever, Hearing loss, Nausea and vomiting, Rashes , Taste disturbanceX, Tooth and tongue discoloration.
Warnings / Precautions
Available Brands
Drug Classification
- 1.6.2.1.4 — Other inhibitors of cell wall synthesis