Mirtazapine
Mirtazapine is a presynaptic a-2 antagonist, increasescentral adrenergic and serotonergic neurotransmission. Mirtazapine is used in the treatment of depression.
Primary Characteristics
It is of Synthetic origin and belongs to Piperazinoazepine.
Molecular Weight: 265.4 · Solubility in Water: Insoluble · Non-proprietary name: Mirtazapine.
Pharmacokinetics
Absorption: Mirtazapine has an oral bioavailability is 50% (±10%).
Distribution: Mirtazapine has a volume of distribution is 4.5(2.8-6.2)l/kg. plasma protein binding is 85%.
Elimination: plasma half-life is 20-40hr, renal excretion is 75%.
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Indications
Mirtazapine is primarily indicated in conditions like Depression, Depressive illness.
Contraindications
None recorded.
Dosage
Mirtazapine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 30 mg/day | 30 mg/day | — | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Mirtazapine in overdosage may give rise to further complications which include Jaundice , Jaundice , Increase in liver enzymes.
The signs and symptoms that are produced after acute overdosage of Mirtazapine are Convulsions , Leucopenia , Hallucinations , Postural hypotension, Tremor, Paresthesia, Mania , Granulocytopenia, Reversible agranulocytosis.
Mirtazapine is known to cause more or less tolerable side effects which are usually transient. These include Agitation , dizziness, Drowsiness, Headache, Increased appetite, Increased weight, Nightmares, Sedation , Skin rashes.
Warnings / Precautions
Interference in Pathology
Mirtazapine may interfere in the diagnosis of Elevation in ALT or AST.
Available Brands
Drug Classification
- 1.24.2.1 — Drugs used in depression