DrugInfoSys

Celecoxib

Drug #1575

Celecoxib is an NSAID, a selective inhibitor of cyclo-oxygenase-2 (COX-2). Celecoxib is used in the treatment of rheumatoid arthritis and osteoarthritis. It is also used for ankylosing spondylitis.

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Primary Characteristics

It is of Synthetic origin and belongs to NSAID.

Molecular Weight: 381.4 · Non-proprietary name: Celecoxib.

Molecular structure of Celecoxib

Pharmacokinetics

Distribution: Celecoxib has a volume of distribution is 500 l/kg. plasma protein binding is 97%.

Elimination: it is metabolised via Liver, plasma half-life is ~97, renal excretion is < 1%.

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Indications

Celecoxib is primarily indicated in conditions like Ankylosing spondylitis, Osteoarthritis, Rheumatoid arthritis.

Celecoxib is also indicated for secondary conditions like Dysmenorrhoea, Pain, Toothache.

Contraindications

Celecoxib is contraindicated in conditions like Asthma, Urticaria, Hypersensitivity.

Dosage

Celecoxib's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
150 mg150 mg—PO
Paediatric Dosage (20kg)
5 mg5 mgEvery 12hfor childeren behaving 10 to 25kg
100 mg100 mgEvery 12hfor childeren behaving over 25kg
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown6 interactions
1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Celecoxib in overdosage may give rise to further complications which include Gi bleeding , Urinary tract infection , GI bleeding, Rhinitis , Hepatotoxicity , Rhinitis , Bronchitis, Pharyngitis, Hepatotoxicity , Myalgia .

Celecoxib produces potentially life-threatening effects which include Myocardial infarction, Hypotension, Heart failure, Death. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Celecoxib are Methemoglobinemia.

Celecoxib is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Constipation , Cough , Diarrhea, Dizziness, dyspepsia, Edema, Flatulence, Headache, Insomnia, Nausea, Pruritus , Rashes , Vomiting .

Warnings / Precautions

It is classifed as pregnancy category C, and should be used with caution during pregnancy only if clearly needed. Avoid use in case of hypersensitivity to celecoxib or any component, sulfonamides, aspirin or other non steroidal anti-inflammatory drugs.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps
100 mg200 mg
Tabs
100 mg200 mg

Multi-Ingredient Combinations

Caps
100 mg200 mg

Storage Conditions

Celecoxib should be stored Caps.

Drug Classification

  1. 1.2.1.3 — Non steroidal anti-inflammatory drugs (NSAIDs)

Manufacturers