Efavirenz

Drug #1569

Efavirenz is an antiretroviral agent, inhibits non-nucleoside reverse transcriptase enzyme. Efavirenz is used in combination with other antiretroviral drugs in the treatment of HIV infection.

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 315.7 · Non-proprietary name: Efavirenz.

Pharmacokinetics

Distribution: Efavirenz has a plasma protein binding is 99.5-99.75%.

Elimination: plasma half-life is 40-55 hr, renal excretion is <1%.

Indications

Efavirenz is primarily indicated in conditions like Epidural block, surgery, HIV infection.

Contraindications

Efavirenz is contraindicated in conditions like Breast feeding.

Dosage

Efavirenz's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
600 mg	600 mg	Every 24h	PO	Take on empty stomach bed time dosing recomended initialy to minimizing CNS side effect.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Efavirenz in overdosage may give rise to further complications which include Insomnia , Amnesia.

Efavirenz is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Abnormal dreams, Anxiety, Crystalluria , Diarrhea, Dizziness, Elevated liver enzyme, Fatigue, Fetal Hepatitis, Headache, Nausea, Pruritus , Rashes , Sinusitis , Sleep disturbance, Suicidal ideations, Vomiting .

Warnings / Precautions

Chronic hepatitis B or C (greatest risk of hepatic side effects), hepatic impairment (avoid if severe); severe renal impairment; pregnancy; elderly; history of mental illness or seizures. RASH: rash usually in first 2 weeks, is the most common side effect; discontinue if severe rash or if rash accompanied by blistering, oral lesions, conjunctivitis, facial oedema, general malaise, or hypersensitivity reaction; if rash mild to moderate may continue without interruption but usually resolves within 1 month.

Interference in Pathology

Efavirenz may interfere in the diagnosis of Liver Function Test (LFT) .

Available Brands

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Single Ingredient

Tabs

200 mg 600 mg

Storage Conditions

Efavirenz should be stored .

Drug Classification

1.6.5.2 — Antiretroviral drugs

Manufacturers

Manufacturers of Efavirenz in Pakistan:

A.J.Mirza Mass