DrugInfoSys

Nicergoline

Drug #1527

Nicergoline is an ergot derivative, which is used for the symtomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. Nicergoline is given orally as well as parenterally.

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Primary Characteristics

It is of Synthetic origin and belongs to Ergot derovation.

Molecular Weight: 484.4 · pKa: 8.4 · Solubility in Water: > 1 in 10000 · Solubility in Alcohol: > 1 in 10 · Non-proprietary name: Nicergoline.

Molecular structure of Nicergoline

Pharmacokinetics

Distribution: Nicergoline has a plasma protein binding is 93 - 95 %.

Elimination: it is metabolised via Extensive, plasma half-life is 3.8 hr, renal excretion is 51 %.

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Indications

Nicergoline is primarily indicated in conditions like Mental sequelae of cerebrovascular disorder, Pruritus.

Contraindications

Nicergoline is contraindicated in conditions like Myocardial infarction, Bradycardia.

Dosage

Nicergoline's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
3 mg3 mg—IMTwice daily.
6 mg6 mg—IVDaily (Infusion)
7.5 mg7.5 mgEvery 8hPO
30 drops30 dropsEvery 8hPO
60 mg60 mg—POdaily in 2 divided dose
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

The signs and symptoms that are produced after acute overdosage of Nicergoline are Severe hypotension.

Nicergoline is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Constipation , Diarrhea, Dizziness, Drowsiness, Dry mouth, Headache, Malaise, Nausea, Pruritus , Skin RashX, Tinnitus, Urticaria, Vertigo.

Warnings / Precautions

Although toxicology studies have not shown nicergoline to have any teratogenic effect, the use of this medicine during pregnancy should be limited to those cases where it is absolutely necessary.

Available Brands

None recorded.

Storage Conditions

Nicergoline should be stored Tab, Powder.

Drug Classification

  1. 1.12.8 — Other cardiovascular preparations
  2. 2.24.6 — Cerebrovascular drugs