Stavudine

Also known as: d4T

Drug #1518

Stavudine is an antiviral agent. Stavudine is a nucleoside reverse transcriptase inhibitor. Stavudine is used in patients with AIDS for whom ZIDOVUDINE is inappropriate. Stavudine is either used alone or in combination with other antiretroviral agents in the treatment of HIV infection.

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Primary Characteristics

Stavudine is also known as d4T.

It is of Synthetic origin.

Molecular Weight: 224.2 · Solubility in Water: 1 in 12 · Non-proprietary name: Stavudine.

Pharmacokinetics

Absorption: Stavudine has an oral bioavailability is 82% (±5%).

Distribution: Stavudine has a volume of distribution is 0.53(0.48-0.58)l/kg. plasma protein binding is negligible.

Elimination: plasma half-life is 1.1(0.85-1.35)hr, renal excretion is 40 % unchanged.

Indications

Stavudine is primarily indicated in conditions like HIV infection.

Contraindications

Stavudine is contraindicated in conditions like Pancreatitis, Peripheral neuropathy, Hypersensitivity, Renal dysfunction.

Dosage

Stavudine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
30 mg	30 mg	Every 12h	PO	Preferably at least 1 hr before food.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown6 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Stavudine in overdosage may give rise to further complications which include Dysesthesia.

Stavudine produces potentially life-threatening effects which include Pancreatitis , Peripheral neuropathy. Careful monitoring is needed with proper medical management.

Stavudine is known to cause more or less tolerable side effects which are usually transient. These include Abnormal dreams, Anorexia , Anxiety, Arthralgia, Cough , Depression, Diarrhea, Dizziness, Drowsiness, Dyspnea, Fatigue, Fever, Flatulence, GI disturbance, Headache, Myalgia, Nausea and vomiting, Rashes , Urticaria.

Warnings / Precautions

It should be used with caution in patients with renal impairemnt. It should be used carefully in patients with a history of peripheral neuropathy and treatment suspended if neuropathy develops. If symptoms resolves on withdrawal stavudine may be resumed at half the previous dose. Patients with ahistory of pancreatitis should also be observed carefully for the signs of pancreatitis during treatment.

Interference in Pathology

Stavudine may interfere in the diagnosis of Increases Serum Bilirubin , Increased transaminases levels.

Available Brands

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Single Ingredient

Caps

30 mg 40 mg

Storage Conditions

Stavudine should be stored Cap, Oral Soln.

Drug Classification

1.6.5.2 — Antiretroviral drugs

Manufacturers

Manufacturers of Stavudine in Pakistan:

A.J.Mirza Hilton Mass