Lacidipine

Drug #1471

Lacidipine is a calcium-channel blocking agent, actions, uses and adverse effects similar to those of nifedipine. Lacidipine is used for the management of hypertension.

← Previous drug Next drug →

Primary Characteristics

It is of Synthetic origin and belongs to Dihydropyridine.

Molecular Weight: 455.5 · Solubility in Water: 15-50 ng/ml · Solubility in Alcohol: 25 mg/ml · Non-proprietary name: Lacidipine.

Pharmacokinetics

Absorption: Lacidipine has an oral bioavailability is 5.5% (±3.5%).

Distribution: Lacidipine has a volume of distribution is 40 l/kg. plasma protein binding is >90%.

Elimination: it is metabolised via Hepatic(extensively), plasma half-life is 7 hr, renal excretion is 30%(metabolite).

Indications

Lacidipine is primarily indicated in conditions like Hypertension.

Contraindications

Lacidipine is contraindicated in conditions like Aortic stenosis, Hypersensitivity, Left ventricular dysfunction.

Dosage

Lacidipine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2 mg	2 mg	Every 24h	PO	May be given upto 4-6 mg/day if needed
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Lacidipine in overdosage may give rise to further complications which include Hypotension , Hypotension , Exacerbated angina, Gingival hypertrophy.

The signs and symptoms that are produced after acute overdosage of Lacidipine are Bradycardia, Hypotension, Tachycardia , Hyperglycemia, Prolonged peripheral vasodilation.

Lacidipine is known to cause more or less tolerable side effects which are usually transient. These include Ankle edema, Cold legs, Dizziness, Dyspnea, Flushing, Headache, Hypotensive crisis , Muscle cramps, Palpitation, Paresthesias, Polyuria, Sexual impotence.

Warnings / Precautions

Lacidipine should be used with caution in patients with kidney or liver disease. Consider decrease in dose of calcium channel blockers and monitor drug response in cirrhosis patients. It should be used with caution in the patient with hypotension. It should not be used in the cardiogenic shocks, recent Myocardial Infarction and in acute unstable angina. Sudden withdrawal of lacidipine might be associated with an exacerbation of angina. The drug should be discontinued in the patient who experience ischaemic pain following its administration.

Available Brands

None recorded.

Storage Conditions

Lacidipine should be stored .

Drug Classification

1.12.3.2 — Calcium antagonists