Gestodene
Also known as: Gestodeno, Gestodenum
Gestodene is hormonal contraceptive given in combination with other hormonal contraceptives. Gestodene is an orally active progestin which is used in combination with the synthetic oestrogen ethinyloestradial for Centraceplian.
Primary Characteristics
Gestodene is also known as Gestodeno, Gestodenum.
It is of Synthetic origin and belongs to Active progestogen.
Molecular Weight: 310.4 · Solubility in Water: Insoluble · Non-proprietary name: Gestodene.
Pharmacokinetics
Absorption: Gestodene has an oral bioavailability is 50% (±50%).
Distribution: Gestodene has a volume of distribution is 0.66 +/- 0.43 l/kg. plasma protein binding is 99.4 %.
Elimination: it is metabolised via liver, plasma half-life is 1.5 hr and 18 hr, renal excretion is Excreted in urine 50% of dose.
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Indications
Gestodene is primarily indicated in conditions like Contraception.
Contraindications
Gestodene is contraindicated in conditions like Breast cancer, Circulatory system disease, Liver diseases, Genital bleeding, Hydatidiform mole, Disturbance of lipid metabolism, Pregnancy.
Dosage
Gestodene's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 37.5 µg | 37.5 µg | — | For 12 days of 28 day cycle as component of menopausal HRT | |
| 75 µg | 75 µg | — | Triphasic Preparation | |
| 75 µg | 75 µg | — | I/M | Monophasic Preparation |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Gestodene in overdosage may give rise to further complications which include Hypertension , Necrotizing pancreatitis.
Gestodene produces potentially life-threatening effects which include Venous thromboembolism, Ischemic heart disease, Cerebrovascular disease, Stroke. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Gestodene are Nausea & vomiting, Withdrawal bleeding in females.
Gestodene is known to cause more or less tolerable side effects which are usually transient. These include Breast swelling, Changes in body weights, Depressive moods, Headache, Membranous dysmenorrhea, Metasma, Nausea and vomiting.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.18.3.1 — Hormonal contraceptives
- 2.18.5 — Progestogens