Dopexamine (HCl)

Drug #1449

Dopexamine (HCl) is a sympathomimetic, stimulates beta-2 adrenoceptorsand peripheral dopamine receptors. It also inhibits neuronal reuptake of noradrenaline. Dopexamine (HCl) is used to provide haemodynamic support that may be required after cardiac surgery or in exacerbation of chronic heart failure.dipexamine (Dopacard) is a synthetic analog related to dopermine with intsinic activity at dopamine D1 and D2 receptors as well as at b2 receptors; it may have others effects such as inhibition of catecholamine up take in patients with law cardiac output, dopexamine infusion significantly increase stroke volume with a decrease in systemic mascular resistance.

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 429.4 · Non-proprietary name: Dopexamine (HCl).

Pharmacokinetics

None recorded.

Indications

Dopexamine (HCl) is primarily indicated in conditions like Cardiac surgery, Chronic heart failure, Heart failure associated with cardiac surgery, Inotropic support and vaso, Sedation of patients receiving intensive care.

Dopexamine (HCl) is also indicated for secondary conditions like Acute exacerbation of chronic heart failure, Sepsis, Shock.

Contraindications

Dopexamine (HCl) is contraindicated in conditions like Hypovolaemia, Myocardial infarction, Phaeochromocytoma, Thyrotoxicosis, Thrombocytopenia, Left ventricular outflow obstruction.

Dosage

Dopexamine (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.5 – 6 mcg/kg	—	—	IV INF	Infused into central or large peripheral wein.
500 mg/kg/min	500 mg/kg/min	—	IV INF	Infused into central or large peripheral wein.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown4 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

The signs and symptoms that are produced after acute overdosage of Dopexamine (HCl) are Hypotension, Nausea, Vomiting, Tachycardia , Ventricular arrhythmias, Tremulousness , Ischemic chest pain.

Dopexamine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Angina, Arrhythmia, Atrial fibrillation, Cardiac failure, Chest pain, Decreased sweating, Dyspnea, Headache, Hypotension , Nausea, Supraventricular tachycardia, Sweating , Tachycardia, Thrombocytopenia, Tremor, Vomiting .

Warnings / Precautions

It should be used with caution in patients with ischemic heart disease or following mayocardial infarction. Care is required in presence of hyperglycemia or hypokalemia. Pre-existing hypotension and reduced vascular resistance should be corrected before begining dopexamine administration.Cuation:- Mycordial infraction , recent angina, hypokalcemia,hyperglycemia;correct hyponolaemia before starting and during treatment monitor blood pressure, pulse,plasma potassium and blood glucose; hyperthysoidism; aviod absupt with drawal.

Available Brands

None recorded.

Storage Conditions

Dopexamine (HCl) should be stored IV Inf .

Drug Classification

1.12.4 — Drugs used in heart failure
2.12.8 — Other cardiovascular preparations