Desflurane

Drug #1446

Desflurane is a volatile halogenated inhalational anaesthetic. Desflurane is a widely used anaesthetic for outpatient surgery because of its rapid onset of action and rapid recovery. It decreases cerebral vascular resistance and cerebral metabolic oxygen consumption. It produces direct skeletal muscle relaxation as well as enhancing the effects of neuromuscular blocking agents.

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Primary Characteristics

None recorded.

Pharmacokinetics

None recorded.

Indications

Desflurane is primarily indicated in conditions like Induction and maintenance of anaesthesia, Induction of anaesthesia, Maintenance of anaesthesia.

Contraindications

Desflurane is contraindicated in conditions like Ischaemic heart disease, Malignant hyperthermia.

Dosage

Desflurane's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.75 MAC	0.75 MAC	—	Inh	For administration after induction with an intravenous induction agent.
1.75 %	1.75 %	—	Inh	General anesthetic: Inhalation, vaporized in a flow of oxygen or oxygen and air, or in a flow of nitrous oxide and oxygen. For administration as sole induction agent: 0.5 to 3% initially, to be increased by 0.5 to 1% every two to three breaths, or as tolerated, until onset of anesthesia.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown5 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Desflurane in overdosage may give rise to further complications which include Cough , Laryngospasm, Oxyhemoglobin desaturation.

Desflurane produces potentially life-threatening effects which include Malignant hyperpyrexia. Careful monitoring is needed with proper medical management.

Desflurane is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Headache, Nausea, Vomiting .

Warnings / Precautions

It should be used with caution in patient with, or at risk from, increased intracranial pressure, coronary artery disease, hypertension, increased heart rate, respiratory, renal or hepatic impairment.

Interference in Pathology

Desflurane may interfere in the diagnosis of Increased blood glucose level.

Available Brands

None recorded.

Storage Conditions

Desflurane should be stored Inhaler.

Drug Classification

1.1.1.2 — Inhalational anesthetics