Cromolyn (Na)

Drug #1443

Cromolyn was synthesized in 1965, as part of an attempt to produce an improved bronchodilator copound. Although cromolyn does not have bronchodilator activity, it was found to inhibit antigen-induced bronchospasm. Currently, its major use is as a prophylactic agent in the treatment of mild to moderate asthma. Cromolyn (Na) is also used as a nasal inhaler to treat seasonal allergic rhinitis, as an ophthalmic solution to treat allergic or vernal conjunctivitis. Cromolyn sodium was approved by the FDA in 1973 and went off patent in May 1993.

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Primary Characteristics

It is of Synthetic origin and belongs to Benzopyran.

Molecular Weight: 512.3 · pK_a: 1.9 · Solubility in Water: 1 in 20 · Solubility in Alcohol: insoluble · Non-proprietary name: Cromolyn (Na).

Pharmacokinetics

Absorption: Cromolyn (Na) has an oral bioavailability is 0.5% (±0.5%).

Distribution: Cromolyn (Na) has a volume of distribution is 0.32 l/kg. plasma protein binding is 57 - 69%.

Elimination: it is metabolised via IV dosage =20min, plasma half-life is oral dose/inhalation >80min, renal excretion is ~ 50% (unchanged).

Indications

Cromolyn (Na) is primarily indicated in conditions like Allergic conjunctivitis, Allergic rhinitis, Asthma, Food allergy, Perennial rhinitis, Seasonal rhinitis.

Contraindications

Cromolyn (Na) is contraindicated in conditions like Hypersensitivity.

Dosage

Cromolyn (Na)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
1.5 drops	1.5 drops	Every 4.8h	Opthalmic
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Cromolyn (Na) is known to cause more or less tolerable side effects which are usually transient. These include Local irritation.

Warnings / Precautions

Withdrawl may lead to recurrence of the symptoms of asthma. If withdrawl is necessary, it has been suggested that the dose should be reduce gradually over a period of one week.

Available Brands

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Multi-Ingredient Combinations

Eye Drops

4 %w/v

Storage Conditions

Cromolyn (Na) should be stored Eye Drops. Eye Oint. Inhaler.

Drug Classification

1.21.6 — Non-specific anticonjunctivitis preparations
2.25.1.2 — Inhalants
3.25.4 — Nasal preparations

Manufacturers

Manufacturers of Cromolyn (Na) in Pakistan:

Ophth-Pharma