Carnitine

Drug #1403

Carnitine is a betaine derivative found in skeletal muscle and liver. Carnitine is required for mitochondrial ß oxidation of fatty acids. Carnitine is involved in energy metabolism. It has been used as an investigational antithyroid and antiangina agent.

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Primary Characteristics

It is of Natural origin.

Molecular Weight: 161.2 · pK_a: 3.8 · Solubility in Water: freely · Solubility in Alcohol: 2500mg/ml · Non-proprietary name: Carnitine.

Pharmacokinetics

Elimination: plasma half-life is 17.4 hrs.

Indications

Carnitine is primarily indicated in conditions like Carnitine deficiency, Pediatric cardiomyopathy, Primary carnitine deficiency, Secondary carnitine deficiency, Valproate toxicity.

Contraindications

None recorded.

Dosage

Carnitine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
2 g/day	2 g/day	—	PO	For solution dosage forms. The dose should be increased slowly while assessing tolerance and therapeutic response.
990 mg	990 mg	Every 8h	PO	For tablet dosage forms.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Carnitine is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Diarrhea, Nausea, Vomiting .

Warnings / Precautions

Carnitine should be used with caution in patients with pre-existing illnesses or allergies.This medication should be used only if clearly needed during pregnancy or lactation.

Available Brands

Click on a strength to view available brands.

Multi-Ingredient Combinations

Syrup

150 mg/5ml

Storage Conditions

Carnitine should be stored Tab, Liq, Caps.

Drug Classification

1.27 — Vitamins, minerals, tonics, and other susbstances

Manufacturers

Manufacturers of Carnitine in Pakistan:

Highnoon