Polidocanol - Drug Monograph | DrugInfoSys ODIS

Primary Characteristics

It belongs to Non-ionic Detergent.

It belongs to sclerosing agent pharmacological group on the basis of mechanism of action.

Molecular Weight: 600 · Non-proprietary name: Polidocanol · pH: 6.5.

Pharmacokinetics

Elimination: plasma half-life is 1.5 hour.

Indications

Polidocanol is primarily indicated in conditions like Oesophageal varices, Varicose veins.

Contraindications

Polidocanol is contraindicated in conditions like Thromboembolism, Hypersensitivity to any component of product.

Dosage

Polidocanol's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.2 ml	0.2 ml	—	inj	the volume per injecton should not be more than 10ml . For Spider veins use 0.5% solution and for reticular veins use 1% solution. Apply gentle pressure to prevent vein rupture. Wear Compression stockings or support Hose on treated legs continuously for 2-3days and for 5-7 days after treatment of spider veins and reticular veins respectively. Advise patient to walk for 15-20 minutes daily for few days. Advise patient to avoid heavy excercise, sunbathing, long plane flights and hot bath or sauna.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Polidocanol in overdosage may give rise to further complications which include Pulmonary embolism , Paresthesia, Dizziness , Loss of consciousness.

Polidocanol produces potentially life-threatening effects which include Anaphylactic shock, Syncope, Cardiac Arrest , Dyspnea, Vaso-vagal attacks, Asthma , Angioedema , Reversible ischemic neurological deficit, Circulatory collapse, cerebrovascular accident, deep vein thrombosis. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Polidocanol are Necrosis.

Polidocanol is known to cause more or less tolerable side effects which are usually transient. These include Dermatitis, Hot flushes, ijection site warmth, injection site discoloration, Injection site hematoma, injection site pain, injection site pruritus, Injection site reactions, Necrosis , neovascularisation, nerve injury, Pain , Pruritus , Pyrexia , skin hyperpigmentation.

Warnings / Precautions

Donot inject polidocanol intra-perivascularly as it can cause pain. Donot inject polidocanol intra-arterially as it can cause necrosis, ischemia,gangerene. Use personal protective equipment. Evacuate personnel to safe areas. Should be use with caution in patients history of allergy and observe patients for anaphylaxis polidocanol should not be used during pregnancy

Available Brands

Click on a strength to view available brands.

Single Ingredient

Eye Gel

Gel

Inj

Oint

Paste

Storage Conditions

Polidocanol should be stored Inj.

Drug Classification

1.13.3.3 — Antipruritics
2.13.11 — Wounds healing agents

Manufacturers

Manufacturers of Polidocanol in Pakistan:

Haroon