DrugInfoSys

Chloroform

Drug #1337

Chloroform is an inhalation anesthetic. Chemically Chloroform is trichloromethane. It was once widely used as an anesthetis and analgesic,and as a carminative, antitussive and counter-irritant, but Chloroform is not used now-a-days due to its toxic effects. The modern discovery of the intoxicant effects of inhalants began with Sir Humphry Davy in 1799, who administered nitrous oxide himself and others. As other anesthetic gases were introduced such as it and ether, they were also used socially. Inhaled gases are the mainstay of anesthesia and are primarily used for the maintenance of anesthesia after administration of an intravenous agent. The depth of anesthesia can be rapidly altered by changing the concentration of inhaled anesthetic. Most of the agents are rapidly eliminated from the body and donot cause post-operative respirtory depression but Chloroform is used rarely due to the serious side effects it produces on heart and liver.

Primary Characteristics

Chloroform is also known as chloromethane, Trichloromrthane.

It is of Synthetic origin and belongs to Chloromethane.

Molecular Weight: 119.4 · Solubility in Water: 1 in 210 · Solubility in Alcohol: miscible · Non-proprietary name: Chloroform.

Molecular structure of Chloroform

Pharmacokinetics

None recorded.

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Indications

Chloroform is primarily indicated in conditions like Anesthesia.

Contraindications

Chloroform is contraindicated in conditions like Diabetes mellitus, Sepsis.

Dosage

None recorded.

Drug Interactions

None recorded.

Side Effects

Chloroform in overdosage may give rise to further complications which include Nephrotoxicity , Cardiac arrhythmias, Hepatotoxicity , Hypotension , Cardiac arrhythmias , Hypotension , Hepatotoxicity , Decreased cardiac output .

Chloroform produces potentially life-threatening effects which include Respiratory depression, Cardiac Arrest , Cardiac arrest. Careful monitoring is needed with proper medical management.

Chloroform is known to cause more or less tolerable side effects which are usually transient. These include Blistering, Burns of skin & mucous membrane, Irritation.

Warnings / Precautions

Patients should observe caution while driving or performing other tasks requiring alertness, because it may cause drowsiness. Patients with chronic disease such as diabetes or hypertension may require adjustment to their therapy before anesthesia. Anesthetics (chloroform) should be given with caution in patients with cardiac, respiratory, kidney or liver impairment.Not to vaporize in presence to flame because of production of harmful gases.

Available Brands

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Multi-Ingredient Combinations

Storage Conditions

Chloroform should be stored Liq, Spirit.

Drug Classification

  1. 1.1.1.2Inhalational anesthetics

Manufacturers

Manufacturers of Chloroform in Pakistan: