Carbimazole
Carbimazole used in the treatment of hyperthyroidism. Carbimazole depresses the formation of thyroid hormone.
Primary Characteristics
It is of Synthetic origin and belongs to Imidazoline.
It belongs to Thyroid peroxidease inhibitor pharmacological group on the basis of mechanism of action and also classified in Antithyroid pharmacological group.
Molecular Weight: 186.2 · Solubility in Water: 1 in 500 · Solubility in Alcohol: 1 in 50 · Non-proprietary name: Carbimazole.
Pharmacokinetics
Absorption: Carbimazole has an oral bioavailability is 95% (±5%), pre-systemic (first-pass) metabolism accounts for 100%.
Distribution: Carbimazole has a volume of distribution is 0.5 l/kg. plasma protein binding is 40%.
Elimination: it is metabolised via via liver & thyroid, plasma half-life is 3-5 hr, renal excretion is 90%.
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Indications
Carbimazole is primarily indicated in conditions like Blocking-replacement, Graves disease, Hyperthyroidism.
Contraindications
Carbimazole is contraindicated in conditions like Nodular goitre, Sub-acute thyroiditis, Post-partum painless thyroiditis.
Dosage
Carbimazole's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 10 mg | 10 mg | Every 8h | PO | Maintenance, for 6-18 Months |
| 40 mg | 40 mg | Every 8h | PO | Initially, As Required |
| Paediatric Dosage (20kg) | ||||
| 0.25 mg/kg | 0.25 mg/kg | Every 8h | Oral | - |
| Neonatal Dosage (3kg) | ||||
| 0.25 mg/kg | 0.25 mg/kg | Every 8h | oral | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Carbimazole in overdosage may give rise to further complications which include Insulin autoimmune syndrome , Cholestatic jaundice , Lupus like syndrome , Nephrotic syndrome , Hepatic necrosis .
Carbimazole produces potentially life-threatening effects which include Agranulocytosis, Oropharyngeal bacterial infection . Careful monitoring is needed with proper medical management.
Carbimazole is known to cause more or less tolerable side effects which are usually transient. These include Arthralgia, Fever, Headache, Loss of hair, Nausea, Urticarial skin rash, Vasculitis.
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.18.8 — Thyroid & antithyroid preparations