DrugInfoSys

Calcium Folinate

Also known as: Calcium Leucovorin

Drug #1262

Calcium Folinate is used as a source of folic acid in megaloblastic anemia. Calcium Folinate is superior to folic acid in counteracting the excessive effects of the folic acid antagonists e.g. methotrexate.

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Primary Characteristics

Calcium Folinate is also known as Calcium Leucovorin.

It is of Synthetic origin.

Molecular Weight: 511.5 · Solubility in Alcohol: Insoluble · Non-proprietary name: Calcium Folinate · pH: 6.8.

Molecular structure of Calcium Folinate

Pharmacokinetics

Elimination: it is metabolised via through Liver.

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Indications

Calcium Folinate is primarily indicated in conditions like As an antidote to methotrexate, Folate deficiency anaemia, Megaloblastic anaemia, Nausea and vomiting, Suspected methotrexate overdosage, To counteract the folate-antagonist action of methotrexate.

Calcium Folinate is also indicated for secondary conditions like HIV infection.

Contraindications

None recorded.

Dosage

Calcium Folinate's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
75 mg75 mgEvery 12hIVTreatment of overdaosage of folic acid antagonists: This dose is followed by 12 mg IM every 6 hours for 4 doses.
15 mg15 mgEvery 24hPOTreatment of megaloblastic anemia. Dose should not exceed 1 mg daily when given IM.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Calcium Folinate in overdosage may give rise to further complications which include Urticaria , Anaphylactoid reactions .

Calcium Folinate is known to cause more or less tolerable side effects which are usually transient. These include Fever, Hypersensitivity reactions.

Warnings / Precautions

alcium Folinate should only be used with methotrexate or 5-FU under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents. In the treatment of inadvertent overdosage of a folic acid antagonist, folinate should be administered as soon as possible; if a period exceeding 4 hours intervenes, the treatment may not be effective.Plasma methotrexate concentration, BUN and creatinine should be measured on days 2, 3 and 4.Parenteral administration of folinate is preferable to oral dosing following chemotherapy with folic acid antagonists if there is a possibility that the patient may vomit and not absorb the folinate.

Available Brands

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Single Ingredient

Inj
15 mg30 mg50 mg

Storage Conditions

Calcium Folinate should be stored Injection. Tab.

Drug Classification

  1. 1.10.1 — Antianemia drugs

Manufacturers

Manufacturers of Calcium Folinate in Pakistan:

AtcoBio PharmaCCLPharmedic