Arginine
Arginine is amino acid produced by the hydrolysis or digestion of proteins. Arginine is one of the hexone bases and supplies the amidine group for the synthesis of creatine. Arginine is also formed by the transfer of nitrogen atom from aspartate to citrulline in the urea cycle. Arginine is effective in the treatment of liver coma and as a stimulant to the pituitary for the release of human growth hormone.
Primary Characteristics
Arginine is also known as monoglutamate.
It is of Natural and Synthetic origin and belongs to Amino acids.
Molecular Weight: 174.2 · Solubility in Water: freely · Solubility in Alcohol: slightly · Non-proprietary name: Arginine.
Pharmacokinetics
None recorded.
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Indications
Arginine is primarily indicated in conditions like Acromegaly, Metabolic alkalosis.
Arginine is also indicated for secondary conditions like Hypertension.
Contraindications
Dosage
Arginine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 375 mg/ kg | 375 mg/ kg | — | IV Inf | Doses vary according to indications. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Arginine in overdosage may give rise to further complications which include Thrombocytopenia .
Arginine is known to cause more or less tolerable side effects which are usually transient. These include Flushing, Headache, Inflammation, Local irritation, Nausea and vomiting.
Warnings / Precautions
Available Brands
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Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.17.9 — Cholagogues & hepatic preparations
Manufacturers
Manufacturers of Arginine in Pakistan: