Factor IX

Also known as: Christmas Factor

Drug #1214

Factor IX used to treat bleeding problems in patients with haemophilia type B.

Primary Characteristics

Factor IX is also known as Christmas Factor.

It is of Natural origin and belongs to Antihaemophillic factor B.

Molecular Weight: 70000 · pK_a: 4.30-4.45 · Solubility in Water: readly · Solubility in Alcohol: insoluble · Non-proprietary name: Factor IX · pH: 6.5 · Isotonic value: 240.

Pharmacokinetics

Distribution: Factor IX has a volume of distribution is 184 ml/kg.

Elimination: plasma half-life is 33 hr.

Indications

Factor IX is primarily indicated in conditions like Blood disorders, Haemophilia.

Contraindications

Factor IX is contraindicated in conditions like Hypersensitivity to any component of product.

Dosage

Factor IX's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0 – 0	—	—	IV	Infuse at a rate not exceeding 2 mL/minute.(225 units/min~2mL/min
30 IU/kg	30 IU/kg	—	IV	Every 3 or 4 days
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Factor IX in overdosage may give rise to further complications which include Urticaria , Hepatitis , HIV vieus transmission.

Factor IX produces potentially life-threatening effects which include Myocardial infarction, Pulmonary embolism, Disseminated intravascular coagulation, deep vein thrombosis. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Factor IX are Hemorrhage , Venous thromboembolism, Myocardial infarction.

Factor IX is known to cause more or less tolerable side effects which are usually transient. These include Chills, Fever, Flushing, Headache, Nausea and vomiting, Unpleasant taste.

Warnings / Precautions

It should be used only if clearly needed during pregnancy.It should be used with cauiton in patients with any pre-existing diseases or any allergies. Before and during injection check heart rate.The dose or rate of infusion may need to be changed if heart rate is too fast.Should be used with care in patients with theomboembolism.

Interference in Pathology

Factor IX may interfere in the diagnosis of Increased Alkaline Phosphatase Levels, Elevation in ALT or AST.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

500 IU

Storage Conditions

Factor IX should be stored Dry Powder . Inj (reconstituted soln).

Drug Classification

1.11.2 — Plasma fractions for specific use

Manufacturers

Manufacturers of Factor IX in Pakistan:

Popular Int.