Fluvastatin

Drug #1191

Fluvastatin is antihyperlipidimic agent. Fluvastatin is a structural analog of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme). It lowers high blood cholesterol levels (High levels of cholesterol cause the blockade of arteries of heart) and prevents coronary atherosclerosis and reduces risk of heart attack.

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Primary Characteristics

Fluvastatin is also known as Fluvastatin Sodium.

It is of Synthetic origin and belongs to Statin Derivative.

It belongs to HMGCoA reductase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antilipemic Agent pharmacological group.

Molecular Weight: 433.5 · Solubility in Water: Insoluble · Solubility in Alcohol: Freely soluble · Non-proprietary name: Fluvastatin.

Pharmacokinetics

Absorption: Fluvastatin has an oral bioavailability is 98%, pre-systemic (first-pass) metabolism accounts for 35% (±35%).

Distribution: Fluvastatin has a volume of distribution is 0.42 l/kg. plasma protein binding is >99%.

Elimination: it is metabolised via Hepatic, plasma half-life is 2.3 hr, renal excretion is 6%.

Indications

Fluvastatin is primarily indicated in conditions like Acute heart failure, Atherosclerosis, Chronic heart failure, Hypercholesterolaemia, Hyperlipidaemias, Hyperlipoproteinaemia.

Contraindications

Fluvastatin is contraindicated in conditions like Liver diseases, Hepatic dysfunction.

Dosage

Fluvastatin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
30 mg	30 mg	Every 24h	PO	Should be taken in evening, Daily regimen 80mg/day should be administered in divided doses.
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown2 interactions

2 interactions

Moderate (Sequence important)1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Fluvastatin in overdosage may give rise to further complications which include Rhabdomyolysis , Angioedema , Myopathy , Anaphylaxis .

The signs and symptoms that are produced after acute overdosage of Fluvastatin are Hepatitis, Pancreatitis.

Fluvastatin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Blurred vision, Dizziness, Dyspepsia , Dyspnea, Elevation of liver enzymes, Headache, Insomnia, Myalgia, Myopathy, Nausea, Nausea and vomiting, Skin rash.

Warnings / Precautions

Fluvastatin should be used with caution in patients with liver disease, severe infection, kidney disease, heart disease, hypothyroidism or any allergies. Heavy drinking of alcohol can increase blood levels of fluvastatin, do not drink heavily while taking fluvastatin. Fluvastatin should not be used during pregnancy or lactation. It should be discontinued if there is marked increase in serum aminotransferases.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Caps

20 mg 40 mg

Tabs

80 mg

Storage Conditions

Fluvastatin should be stored Caps.

Drug Classification

1.12.6 — Lipid-regulating drugs /Anti-atheromas

Manufacturers

Manufacturers of Fluvastatin in Pakistan:

Novartis