Lercanidipine (HCl)
Lercanidipine (HCl) is a long acting calcium channel antagonistwith actions similar to Nifedipine. Used as a once-daily treatment for hypertension.it exerts its antihypertensive effect by inhibiting the influx of extracellular calcium across the cell membranes of myocardial and vascular smooth muscle. Serum calcium levels remain unchanged.
Primary Characteristics
It belongs to Dihydropyridine.
It belongs to Calcium L-channel antagonist pharmacological group on the basis of mechanism of action.
Molecular Weight: 648.2 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Lercanidipine (HCl).
Pharmacokinetics
Distribution: Lercanidipine (HCl) has a plasma protein binding is 98 %.
Elimination: plasma half-life is 2.5 hr, renal excretion is 50 %.
Advertisement
Indications
Lercanidipine (HCl) is primarily indicated in conditions like Hypertension, Mild to moderate hypertension.
Contraindications
None recorded.
Dosage
Lercanidipine (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 15 mg | 15 mg | Every 24h | PO | Daily before food. |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended for this age group. | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Lercanidipine (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Asthenia , Diarrhea, Dizziness, Epigastric pain, Fatigue, Flushing, GI disturbance, Headache, Hypotension , Nausea, Palpitation, Peripheral edema, Tachycardia, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.12.3.2 — Calcium antagonists
Manufacturers
Manufacturers of Lercanidipine (HCl) in Pakistan: