Calcifediol
Also known as: 25-OH Vitamin D3
Calcifediol is a vitamin D3, a fat soluble sterol, sometimes considered to be hormone or hormone precursor. Calcifediol is involved in promoting normal bone development in body by regulating calcium, phosphorus and minerals. Vitamin D is a secosteroid and sometimes popularly known as the 'sunshine vitamin' because formed in the skin from 7-dehydrocholesterol under the influence of ultraviolet irradiation. Calcifediol is also found in certain foods. Fish liver oils especially code liver oil are good sources of vitamin D.Calcifediol is used topically as a teratment of psoriasis
Primary Characteristics
Calcifediol is also known as 25-OH Vitamin D3.
It is of Synthetic origin and belongs to Secochloesta.
It belongs to Vitamin D agonist pharmacological group on the basis of mechanism of action.
Molecular Weight: 400.6 · Solubility in Water: low · Solubility in Alcohol: soluble · Non-proprietary name: Calcifediol.
Pharmacokinetics
Absorption: Calcifediol has an oral bioavailability is 65% (±5%).
Distribution: Calcifediol has a plasma protein binding is high.
Elimination: it is metabolised via hepatic & renal, plasma half-life is 12 days.
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Indications
Calcifediol is primarily indicated in conditions like Cholestasis, Hyperparathyroidism, Hypoparathyroidism, Malabsorption, Nephrotic syndrome, Nutritional osteomalacia, Renal failure, Short bowel syndrome, Vitamin D deficiency rickets, Vitamin D-resistant rickets.
Contraindications
Calcifediol is contraindicated in conditions like Hypercalcaemia, Granulomatous disease.
Dosage
Calcifediol's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 150 mcg | 150 mcg | Every 24h | PO | Every alternate day. |
| Paediatric Dosage (20kg) | ||||
| 0.05 ug/kg | 0.05 ug/kg | — | Oral | Single dose |
| Neonatal Dosage (3kg) | ||||
| 0.075 ug/kg | 0.075 ug/kg | — | Oral | Single dose |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Calcifediol in overdosage may give rise to further complications which include Urinary stone formation .
Calcifediol produces potentially life-threatening effects which include Hypercalcemia, Hyperphosphatemia, Hypermagnesemia, Calcification in arteries & soft tissues . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Calcifediol are Hypercalcemia.
Calcifediol is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Apathy, Cardiac arrhythmias , Dehydration , Headache, Nausea, Polyuria, Somnoparalytic ileus, Thirst, Vomiting , Weakness.
Warnings / Precautions
Available Brands
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Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.27 — Vitamins, minerals, tonics, and other susbstances