DrugInfoSys

Fluorometholone

Drug #1124

Fluorometholone is a corticosteroid. Chemically Fluorometholone is 9-Fluoro-11ß,17-dihydroxy-6a-methylpregna-1, 4-diene-3, 20-dione. Fluorometholone is used in the local treatment of inflammmation when applied as eye drops.

Primary Characteristics

It is of Synthetic origin and belongs to Corticosteroid.

It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Corticosteroid Opthalmic pharmacological group. It is also classified under Opthalmic Products .

Molecular Weight: 376.5 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Fluorometholone.

Molecular structure of Fluorometholone

Pharmacokinetics

None recorded.

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Indications

Contraindications

Fluorometholone is contraindicated in conditions like Fungal infection, Viral infection, Herpes simplex keratitis, Herpes simplex infections.

Dosage

Fluorometholone's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
0.175 %w/v0.175 %w/vEvery 12hOphthalmicIf needed, frequency may be increased to 4 times/day.
Paediatric Dosage (20kg)
0.1 %0.1 %Opthalmic As Required
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Fluorometholone in overdosage may give rise to further complications which include Increased IOP (intraocular pressure), Glaucoma , Cataract, Optic neuritis and atrophy .

Fluorometholone is known to cause more or less tolerable side effects which are usually transient. These include Delayed wound healing, Field defects, Secondary ocular infection, Visual acuity.

Warnings / Precautions

Fluorometholone should be used with caution in patients with active tuberculosis infection of respiratory tract or in untreated fungal, bacterial or systemic viral infections. Corticosteroids should only be used systemically with great caution in the presence of congestive heart failure (CHF), recent myocardial infraction (MI), hypertension, diabetes mellitus, epilepsy, glaucoma, hypothyroidism, liver failure, osteoporosis, peptic ulceration or renal impairment. Children may be at increase risk of some adverse effects, corticosteroid causes growth retardation and prolonged use is rarely justified. Passive immunization is recommended to non-immune patients who do come in contact with chickenpox or measles. Live vaccine should not be given to patients receiving high dose systemic corticosteroid therapy nor for atleast 3 months afterwards, killed vaccine or toxoids may be given, although the response may be attenuated. During prolong treatment with corticosteroids, patients should be examined regularly, sodium intake may need to be reduced and calcium and potassium supplement may be necessary. Patient should carry cards given full details of their corticosteroid therapy. Avoid use during pregnancy. Use nasal steroids with caution until healing has occurred.

Available Brands

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Single Ingredient

Multi-Ingredient Combinations

Eye Oint

Storage Conditions

Fluorometholone should be stored Eye Susp.

Drug Classification

  1. 1.21.2.1Corticosteroids

Manufacturers