Estrogens Conjugated

Also known as: Estrogen, Estrone, Hydrogen Sulfate

Drug #1110

Estrogens are important in the development and maintenance of the female urogenital system and secondary sex characteristics. Conjugated estrogen is a mixture of estrogens (hormone), obtained exclusively from natural sources, blended to represent the average composition of material derived from pregnant mare's urine. It contains the sodium salts of water soluble sulfate esters of estrone, equilin and 17 a-dihydroequilin, together with smaller amounts of 17a estradiol, equilenin, 17ß dihydroequilin, 17ß dihydroequilenin, 17ß estradiol and delta 8, 9 dehydroestrone. The pharmacologic effects of conjugated estrogens are similar to those of endogenous estrogens.

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Primary Characteristics

Estrogens Conjugated is also known as Estrogen, Estrone, Hydrogen Sulfate.

It belongs to Oestrone Sulphate.

It is classified in Estrogen Derivatives pharmacological group. It is also classified under Diuretics .

pK_a: 19.96 · Solubility in Water: 0.0036 mg/ml · Solubility in Alcohol: null · Non-proprietary name: Estrogens Conjugated.

Molecular structure of Estrogens Conjugated

Pharmacokinetics

Elimination: it is metabolised via Hepatic, plasma half-life is 7.4 hrs.

Indications

Estrogens Conjugated is primarily indicated in conditions like Oestrogen deficiency, Osteoporosis, Urethritis, Vaginitis.

Estrogens Conjugated is also indicated for secondary conditions like Abnormal uterine bleeding.

Contraindications

Estrogens Conjugated is contraindicated in conditions like Breast cancer, Genital tract bleeding, Thromboembolism, Thrombophlebitis.

Dosage

Estrogens Conjugated's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.3 – 1.25 mg	—	Every 24h	PO	As required
1.25 g	1.25 g	Every 24h	Topical	For three week of a 4 week cycle
Paediatric Dosage (20kg)
1.25 – 2.5 mg	—	Every 3h	PO	For palliative treatment of prostatic carcinoma
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown9 interactions

10 interactions

Major3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Estrogens Conjugated in overdosage may give rise to further complications which include Pancreatitis , Cholestatic jaundice , Cholestatic jaundice .

Estrogens Conjugated is known to cause more or less tolerable side effects which are usually transient. These include Abdominal cramps, Alopecia, Amenorrhea, Bloating , Breakthrough bleeding, Chloasma , Menstrual irregularity, Nausea, Rashes , Spotting , Vomiting .

Warnings / Precautions

Estrogen conjugate should be used with caution in patients with medical history, including family medical history, especially breast lumps and cancer, high blood pressure, diabetes, asthma, epilepsy (seizures), migraine headaches, liver, heart or kidney disease, depression, toxemia (high blood pressure during pregnancy), jaundice (yellowing of skin or eyes) during pregnancy, excessive weight gain and fluid retention during the menstrual cycle or if have uterine fibroid tumors. Before having surgery, tell the doctor about the use of the drug. Do not use this medication during pregnancy or lactation. This medication may cause fetal harm. Cigarette smoking can increase the chance of blood clots while using this medication (especially in women pass the age of 35). Higher strengths are more likely to cause melasma (darkening of skin), sunlight may intensify this darkening, so avoid prolonged sun exposure and sunlamps. Consult the doctor regarding use of sunscreens and protective clothing.

Interference in Pathology

Estrogens Conjugated may interfere in the diagnosis of Impairment of Glucose Tolerance .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

0.3 mg 0.625 mg 1.25 mg

Storage Conditions

Estrogens Conjugated should be stored Inj. Inj (reconstituted soln).

Drug Classification

1.18.4 — Estrogens, their combinations and related preparations

Manufacturers

Manufacturers of Estrogens Conjugated in Pakistan:

Benson Global Pfizer Zafa