Triptorelin
Triptorelin is a growth hormone analogue. It supresses the release of growth hormone and reduces the circulating concentrations of testosterone and is used for suppression of advanced prostate cancer.
Primary Characteristics
It belongs to Peptide.
It belongs to LH-RH agonist pharmacological group on the basis of mechanism of action and also classified in GnRH Analogue pharmacological group. It is also classified under Hormones .
Molecular Weight: 1311.4 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Triptorelin.
Pharmacokinetics
Elimination: plasma half-life is 7.5 hr.
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Indications
Triptorelin is primarily indicated in conditions like Advanced prostate cancer, Prostatic cancer, Uterine fibroids.
Contraindications
Triptorelin is contraindicated in conditions like Spinal metastasis.
Dosage
Triptorelin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 3 mg | 3 mg | — | IM | Every 28th Day for 6 Months |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not applicable in paeds | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not applicable in this age group | |
Drug Interactions
None recorded.
Side Effects
Triptorelin in overdosage may give rise to further complications which include Hypertension .
Triptorelin is known to cause more or less tolerable side effects which are usually transient. These include Asthma, Decreased libido, Dysuria, Fever, Hair loss, Headache, Hot flushes, Impotence, Phlebitis , VertigoX.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.8.3 — Hormones and antihormones
- 2.18.6 — Ovulation stimulants
Manufacturers
Manufacturers of Triptorelin in Pakistan: