Tianeptine

Drug #1067

Tianeptine used as an oral antidepressant, acts by increasing the presynaptic reuptake of serotonin.

Primary Characteristics

It belongs to Benzothiazepine.

It is classified in Antidepressant pharmacological group. It is also classified under Psychotherapeutic Drugs .

Molecular Weight: 459.9 · Solubility in Water: null · Solubility in Alcohol: null · Non-proprietary name: Tianeptine.

Pharmacokinetics

Distribution: Tianeptine has a plasma protein binding is 94 %.

Elimination: it is metabolised via Hepatic, renal excretion is 8 %.

Indications

Tianeptine is primarily indicated in conditions like Depression.

Contraindications

Tianeptine is contraindicated in conditions like Pregnancy, Lactation.

Dosage

Tianeptine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
12.5 mg	12.5 mg	Every 8h	PO
Paediatric Dosage (20kg)
0 – 0	—	—		Not recommended in this age group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

None recorded.

Side Effects

Tianeptine in overdosage may give rise to further complications which include Respiratory depression .

Tianeptine is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Asthenia , Backache , Drowsiness, Dry mouth, Epigastric pain, Hot flushes, Nightmares, Tremors.

Warnings / Precautions

Tianeptine medicine should not be used during pregnancy as it may be harmful to the unborn baby. Seek medical advice from your doctor. Tianeptine has a short half life. It is exceptionally important that patient adhere to taking their regularly scheduled doses. Do not suddenly stop taking Tianeptine. You must gradually reduce the dose or you may get a dangerous increase in blood pressure.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

12.5 mg

Storage Conditions

Tianeptine should be stored Tabs.

Drug Classification

1.24.2.1 — Drugs used in depression

Manufacturers

Manufacturers of Tianeptine in Pakistan:

Servier