Tacalcitol
Tacalcitol is a synthetic analogue of calcitrol, active form of a fat soluble vitamin D3. Vitamin D, sometimes considered to be a hormone or a hormone precursor. Tacalcitol is involved in promoting normal bone development in body by regulating calcium, phosphorus and minerals. Vitamin D is a secosteroid and sometimes known as the 'sunshine vitamin' because formed in the skin from 7-dehydrocholesterol under the influence of ultraviolet irradiation. Tacalcitol is also found in certain foods. Fish liver oils, especially code liver oil are good sources of vitamin D. Dairy products contain some vitamin but the potency varies with season.
Primary Characteristics
It belongs to Vitamin D agonist pharmacological group on the basis of mechanism of action and also classified in Vitamin D Analogue pharmacological group.
Solubility in Water: Insoluble · Solubility in Alcohol: Insoluble · Non-proprietary name: Tacalcitol.
Pharmacokinetics
None recorded.
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Indications
Tacalcitol is primarily indicated in conditions like NSAID-associated ulceration, Pneumothorax.
Contraindications
Tacalcitol is contraindicated in conditions like Hypersensitivity to any component of product.
Dosage
Tacalcitol's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 3 mcg | 3 mcg | Every 24h | Topical | For 12 Weeks in a year for 2 Years |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
None recorded.
Side Effects
Tacalcitol is known to cause more or less tolerable side effects which are usually transient. These include Burning, Itching, Local irritation, Redness, Tingling .
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.13.9 — Anti-psoriatics
- 2.27 — Vitamins, minerals, tonics, and other susbstances
Manufacturers
Manufacturers of Tacalcitol in Pakistan: