DrugInfoSys

Sparfloxacin

Drug #1026

Sparfloxacin is a fluoroquinolone antibiotic. Sparfloxacin is a new fluoroquinolone recently approved by FDA. Sparfloxacin is used to treat a large variety of bacterial infections, such as respiratory tract infections, middle ear infections, skin infections and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Sparfloxacin is important to take the drug for the full time period as prescribed, discontinuation of the drug may result in ineffective treatment.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Fluoroquinolone.

It belongs to DNA Gyrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Quinolone pharmacological group.

Molecular Weight: 392.4 · Solubility in Water: Insoluble · Solubility in Alcohol: very slightly soluble · Non-proprietary name: Sparfloxacin.

Molecular structure of Sparfloxacin

Pharmacokinetics

Distribution: Sparfloxacin has a volume of distribution is 3.9 ± 0.8 l/kg. plasma protein binding is 45 %.

Elimination: it is metabolised via Hepatic, plasma half-life is 20 hr, renal excretion is 10 %.

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Indications

Sparfloxacin is primarily indicated in conditions like Acne, Bacterial infections, Bronchitis, Burns, Conjuctivitis, Cystitis, Dysenteries, Folliculitis, Impetigo, Otitis media, Pneumonia, Prostatitis, Pyelonephritis, Respiratory tract infections, Sinusitis, Superficial infections, Surgical infections, Tonsillitis, Urethritis.

Contraindications

Sparfloxacin is contraindicated in conditions like Hypersensitivity.

Dosage

Sparfloxacin's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
150 mg150 mgEvery 12hPOMaintenance.
400 mg400 mgEvery 24hPOInitially.
Paediatric Dosage (20kg)
0 – 0——Not recommended in this age group
Neonatal Dosage (3kg)
0 – 0——Not recommended in this age group

Drug Interactions

Unknown1 interaction
2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Sparfloxacin in overdosage may give rise to further complications which include Anaemia .

Sparfloxacin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Agitation , Anxiety, Arthralgia, Delirium , Diarrhea, Eosinophilia, Insomnia, Leukopenia, Myalgia, Rashes , Sleep disturbance, Vomiting .

Warnings / Precautions

Sparfloxacin should be used with caution in patients with any allergy, previous drug reactions (rash) to sunlight, kidney disease, heart conditions, certain mental conditions (psychosis), blood vessel disease (carotid arteries), brain disorders (e.g.seizures or cancer) or tendon problems. Exposure to direct or indirect sunlight, tanning lamps etc. should be avoided for the entire treatment period and five days beyond. Only sunscreens which block UV-A rays (e.g.octocrylene or Parsol-1789 containing products) have been effective protection, along with adequate clothing. Limit alcohol, because this drug could cause drowsiness, and alcohol can intensify drowsiness. Patient should observe caution while driving or performing tasks requiring mental alertness. It should be used only when clearly needed during pregnancy or lactation. This antibiotic is not recommended for use in persons under 18 years old. Avoid repeated or prolonged use of this medication because prolonged or repeated periods may result in a secondary infection (e.g.oral, bladder or vaginal yeast infection).

Interference in Pathology

Sparfloxacin may interfere in the diagnosis of Increased Values for LFTs .

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs
100 mg200 mg500 mg

Storage Conditions

Sparfloxacin should be stored Tab.

Drug Classification

  1. 1.6.2.2.2 — Quinolones

Manufacturers