Bovine Insulin

Drug #102

Insulin is a hormone produced by the beta cells of the islets of langerhans of the pancres and consists of 2 chains of aminoacids. It contains 51 amino acid arranged in two chains (A and B) joined together by disulfide linkage. In 1921, Banting and Best extracted insulin from the pancrease and demonstrated its therapeutic effects in diabetic dogs and human subjects.

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Primary Characteristics

It is of Natural origin and belongs to Polypeptide.

It belongs to Insulin agonist pharmacological group on the basis of mechanism of action and also classified in Antidiabetic Agent, Insulin pharmacological group.

Molecular Weight: 5734 · pK_a: Amphoteric · Solubility in Water: 1 in 100 · Solubility in Alcohol: < 1 in 10000 · Non-proprietary name: Bovine Insulin.

Pharmacokinetics

Absorption: Bovine Insulin has an oral bioavailability is 0.5% (±0.5%), pre-systemic (first-pass) metabolism accounts for 100%.

Distribution: Bovine Insulin has a volume of distribution is 0.1-0.2 l/kg. plasma protein binding is variable.

Elimination: it is metabolised via hepatic & renal, plasma half-life is 4-9 min.

Indications

Bovine Insulin is primarily indicated in conditions like Diabetes mellitus, Hyperkalaemia.

Contraindications

Bovine Insulin is contraindicated in conditions like Hypersensitivity.

Dosage

Bovine Insulin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.25 IU/ kg	0.25 IU/ kg	Every 24h	IV
7.5 IU	7.5 IU	Every 24h	SC	Dose should be adjusted according to patient's blood glucose level.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown7 interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Bovine Insulin produces potentially life-threatening effects which include Hypoglycemia. Careful monitoring is needed with proper medical management.

Bovine Insulin is known to cause more or less tolerable side effects which are usually transient. These include Allergy , Antibody formation, Lipoatrophy.

Warnings / Precautions

It should be used with caution in case of bovine hypersensitivity, breast feeding, coma, diarrhea, fever, infections, porcine hypersensitivity, renal inpairment, surgery, thyroid disease, trauma, and vomiting.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj

100 IU/ml

Storage Conditions

Bovine Insulin should be stored IM Inj, SC Inj, IV Inf . Powder.

Drug Classification

1.18.7.1 — Insulins

Manufacturers

Manufacturers of Bovine Insulin in Pakistan:

Zafa